A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18703587.
- Also identified by DOI 10.1093/bioinformatics/btn431 and PMC identifier 2562017.
- Licence recorded as CC BY-NC.
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Abstract
We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.
Medical subject headings
- Ribonucleoproteins, Small Nuclear
- Spliceosomes
- Zinc Fingers
- tRNA Methyltransferases