Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18706726.
- Also identified by DOI 10.1016/j.radonc.2008.07.018.
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Abstract
Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.
Medical subject headings
- Antigens, Nuclear
- DNA-Binding Proteins
- Hypoxia
- Uterine Cervical Neoplasms