Multiple effects of HMG-CoA reductase inhibitors (statins) besides their lipid-lowering function.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 18709024.
- Also identified by DOI 10.1038/ki.2008.323.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The paper by Sharyo et al. shows that statins reduce the severity in a model of renal-ischemia reperfusion injury and raises the therapeutic possibility of using statins as pharmacological intervention against acute kidney injury. This, together with previous studies, indicates that statins exert a wide spectrum of anti-inflammatory, immunomodulatory, and protective effects besides their lipid-lowering function.
Medical subject headings
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Kidney
- Reperfusion Injury