Macroautophagy: a mechanism for mediating cell death or for promoting cell survival?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18709025.
- Also identified by DOI 10.1038/ki.2008.325.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Macroautophagy is a ubiquitous mechanism for the bulk removal of macromolecules and cell organelles from the cell. Periyasamy-Thandavan and colleagues report that cisplatin activates autophagy in renal tubular cells and that autophagy plays a role in decreasing apoptosis of tubular cells induced by cisplatin. This finding provides novel evidence that autophagy may play a role in ameliorating the effects of acute injury on the kidney.
Medical subject headings
- Autophagy
- Cell Death
- Cell Survival