Functional gene polymorphisms in canadian aboriginal populations with high rates of tuberculosis.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 18713057.
- Also identified by DOI 10.1086/592049.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The present study determined whether a pattern of functional single-nucleotide polymorphisms (SNPs) was present that could predispose a Dené cohort to a suboptimal response to Mycobacterium tuberculosis. Compared with a Caucasian cohort, the Dené and Cree were found to maintain a significantly higher frequency of SNPs associated with low expression of vitamin D receptor (VDR), interferon (IFN)-gamma (+874), and tumor necrosis factor-alpha (-308) and high production of monocyte chemoattractant protein (MCP)-1 (-2518) and interleukin (IL)-6 (-174). Given the roles played by IFN-gamma and VDR in facilitating macrophage containment of M. tuberculosis and the opposing role of MCP-1 and IL-6, the observed allelic variation by ethnicity may in part contribute to the high rates of tuberculosis among the Dené.
Medical subject headings
- Cytokines
- Genetic Predisposition to Disease
- Indians, North American
- Polymorphism, Single Nucleotide
- Receptors, Calcitriol
- Tuberculosis