Silencing HIV-1 In Vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18724929.
- Also identified by DOI 10.1016/j.cell.2008.08.004.
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Abstract
RNA interference holds great promise for antiviral therapy, but delivering effective quantities of small interfering RNAs (siRNAs) into the right target cells in vivo represents a major challenge. Kumar et al. (2008) now report a technique to target siRNAs specifically to T cells to suppress viral infection in a humanized mouse model of HIV/AIDS.
Medical subject headings
- HIV Infections
- HIV-1
- RNA Interference
- RNA, Small Interfering