Linking retroelements to autoimmunity.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18724930.
- Also identified by DOI 10.1016/j.cell.2008.08.010.
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Abstract
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.
Medical subject headings
- Autoimmunity
- DNA, Single-Stranded
- Exodeoxyribonucleases
- Phosphoproteins
- Retroelements