A tale of too many centrosomes.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18724931.
- Also identified by DOI 10.1016/j.cell.2008.08.007.
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Abstract
Having the correct number of centrosomes is crucial for proper chromosome segregation during cell division and for the prevention of aneuploidy, a hallmark of many cancer cells. Several recent studies (Basto et al., 2008; Kwon et al., 2008; Yang et al., 2008) reveal the importance of mechanisms that protect against the consequences of harboring too many centrosomes.
Medical subject headings
- Centrosome
- Mitosis
- Neoplasms