Speeding up the evaluation of new agents in cancer.
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Where this comes from
- Record sourced from PubMed, PMID 18728279.
- Also identified by DOI 10.1093/jnci/djn267 and PMC identifier 2528020.
- Licence recorded as CC BY-NC.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Despite both the increase in basic biologic knowledge and the fact that many new agents have reached various stages of development during the last 10 years, the number of new treatments that have been approved for patients has not increased as expected. We propose the multi-arm, multi-stage trial design as a way to evaluate treatments faster and more efficiently than current standard trial designs. By using intermediate outcomes and testing a number of new agents (and combinations) simultaneously, the new design requires fewer patients. Three trials using this methodology are presented.
Medical subject headings
- Antineoplastic Agents
- Clinical Trials as Topic
- Drug Approval
- Neoplasms
- Research Design