The effect of gold nanorods on cell-mediated collagen remodeling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18729419.
- Also identified by DOI 10.1021/nl802142h and PMC identifier 2651024.
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Abstract
Cardiac fibroblasts, the noncontractile cells of the heart, contribute to myocardial maintenance through the deposition, degradation, and organization of collagen. Adding polyelectrolyte-coated gold nanorods to three-dimensional constructs composed of collagen and cardiac fibroblasts reduced contraction and altered the expression of mRNAs encoding beta-actin, alpha-smooth muscle actin, and collagen type I. These data show that nanomaterials can modulate cell-mediated matrix remodeling and suggest that the targeted delivery of nanomaterials can be applied for antifibrotic therapies.
Medical subject headings
- Collagen
- Drug Delivery Systems
- Gold
- Metal Nanoparticles