Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18729780.
- Also identified by DOI 10.1086/592053 and PMC identifier 2574921.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice.
Medical subject headings
- Bacterial Toxins
- Community-Acquired Infections
- Exotoxins
- Leukocidins
- Methicillin Resistance
- Pneumonia, Staphylococcal
- Staphylococcal Skin Infections
- Staphylococcus aureus