Human platelets attenuate Aspergillus species via granule-dependent mechanisms.
basic_science · Level V
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- Record sourced from PubMed, PMID 18752432.
- Also identified by DOI 10.1086/591458 and PMC identifier 2980866.
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Abstract
Using laser scanning microscopy, we investigated whether platelets are capable of internalizing Aspergillus conidia and examined Aspergillus-platelet adherence. The influence of platelets on fungal growth was evaluated by assessing galactomannan (GM) release, hyphal elongation, and colony size. A secretion assay with [(3)H]-serotonin (5-hydroxytryptamine [5-HT]) was performed. Exposure to platelets resulted in significantly decreased GM release (p<.05), hyphal elongation (p<.001), colony size, pigmentation, and 5-HT release ( p<.05). A lack of antifungal effects was observed with the microfilament inhibitor cytochalasin D. Platelets attenuate the virulence of Aspergillus species in vitro on the basis of granule-dependent effects.
Medical subject headings
- Aspergillus
- Aspergillus fumigatus
- Blood Platelets
- Cytoplasmic Granules