Bacillus Calmette-Guerin and interleukin-2 for treatment of superficial bladder cancer.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 1875490.
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Abstract
A total of 22 patients with bladder cancer received bacillus Calmette-Guerin (BCG) and interleukin-2. Significant bladder tumor remissions were noted in 15 of 17 patients (88%). Of 5 patients with carcinoma in situ 1 was noncompliant and he died of carcinoma in situ. The other 4 patients are in remission. BCG alone was instilled in 22 additional patients with superficial bladder cancer. The remission rates were encouraging. Of the 22 patients 13 (59%) had remission of the bladder tumor. A half dose of BCG (60 mg.) is adequate when given weekly for 6 weeks. Maintenance therapy is important as noted in both of our clinical arms. BCG and interleukin-2 therapy results in a higher remission rate.
Medical subject headings
- BCG Vaccine
- Interleukin-2
- Urinary Bladder Neoplasms