Replication licensing and cancer--a fatal entanglement?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18756287.
- Also identified by DOI 10.1038/nrc2500 and PMC identifier 2577763.
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Abstract
Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under- or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.
Medical subject headings
- Cell Cycle Proteins
- Cell Transformation, Neoplastic
- DNA Replication
- Neoplasms
- Nuclear Proteins