Let's look at cysts from both sides now.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18756294.
- Also identified by DOI 10.1038/ki.2008.357.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In the years since identification of autosomal-dominant polycystic kidney disease (ADPKD) genes, the lag time between initial understanding and translation to therapy has decreased rapidly. Albaqumi and colleagues describe a promising approach to slow ADPKD cyst enlargement through inhibition of the basolateral KCa3.1 K(+) channel, using a nontoxic small molecule with a close congener poised for rapid entry into the clinic. Cyst fluid accumulation can be blocked from both sides now.
Medical subject headings
- Intermediate-Conductance Calcium-Activated Potassium Channels
- Polycystic Kidney, Autosomal Dominant