Pontin and reptin, two related ATPases with multiple roles in cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18757398.
- Also identified by DOI 10.1158/0008-5472.CAN-08-0547.
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Abstract
Studies in model organisms or cultured human cells suggest potential implications in carcinogenesis for the AAA+ ATPases Pontin and Reptin. Both proteins are associated with several chromatin-remodeling complexes and have many functions including transcriptional regulation, DNA damage repair, and telomerase activity. They also interact with major oncogenic actors such as beta-catenin and c-myc and regulate their oncogenic function. We only now begin to get insight into the role of Pontin and Reptin in human cancers.
Medical subject headings
- Carrier Proteins
- DNA Helicases
- Neoplasms