Membrane redox state and apoptosis: death by peroxide.
review · Level V
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- Record sourced from PubMed, PMID 18762018.
- Also identified by DOI 10.1016/j.cmet.2008.08.004.
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Abstract
Membrane redox state is governed by the complex interplay between oxidation of unsaturated fatty acids and lipophilic antioxidants. In this issue of Cell Metabolism, Seiler et al. (2008) show that a lipid oxidase, 12/15-lipoxygenase, and a membrane antioxidant enzyme, glutathione peroxidase-4, interact to regulate a novel redox-dependent cell death pathway.
Medical subject headings
- Apoptosis
- Cell Membrane
- Glutathione Peroxidase
- Lipid Peroxides
- Oxidative Stress