Local toxicity with subcutaneous methadone. Experience of two centers.

Bruera, E; Fainsinger, R; Moore, M; Thibault, R; Spoldi, E; Ventafridda, V · Pain · 1991

case_series · Level IV

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Abstract

We report on 8 patients treated with subcutaneous methadone for cancer-related pain at 2 institutions. The success of other subcutaneous agents for pain control has been well demonstrated. It was felt that methadone would be useful due to its low cost. Unfortunately, 7 of the 8 patients experienced adverse reactions at the subcutaneous sites requiring cessation of subcutaneous methadone.

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