Association of cyclooxygenase-2 and interleukin-1 receptor antagonist gene polymorphisms with the time interval between labor induction and delivery.

Abstract

The interval between induction and delivery may change in association with different polymorphisms in genes regulating inflammation. Seventy participants in a trial for induction of labor at term were tested for a -765 G>C cyclooxygenase-2 and an intron 2 length interleukin-1 receptor antagonist gene polymorphism. The interleukin-1 receptor antagonist allele 2 frequency was 33.3% in the 12 women who delivered at < or =10 hours, compared with 13.8% in those delivered >10 hours (P = .03). The interleukin-1 receptor antagonist allele 2 frequency was 25.0% in women induced because of postdates as opposed to 7.9% induced for other indications (P = .01). The cyclooxygenase-2 allele C frequency was 30.0% in 35 women delivered at < or =20 hours as opposed to 11.4% in women delivered at >20 hours (P = .01). The cyclooxygenase-2 allele C frequency was 26.9% in 26 subjects induced because of postdates as opposed to 13.6% induced for other indications (P = .07). Cyclooxygenase-2 allele C and interleukin-1 receptor antagonist allele 2 are associated with a reduced time interval from labor induction to delivery.