A protein scaffold plays matchmaker for chordin.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18775302.
- Also identified by DOI 10.1016/j.cell.2008.08.024.
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Abstract
In this issue, Inomata et al. (2008) report that the scaffold protein Olfactomedin 1 (ONT1) recruits the Tolloid proteases to their substrate Chordin, an antagonist of bone morphogenetic proteins (BMPs), during development of the frog embryo. Consequently, ONT1 expression in the organizer of the late gastrula stabilizes the gradient of BMP signaling that is essential for dorsoventral patterning.
Medical subject headings
- Extracellular Matrix Proteins
- Glycoproteins
- Intercellular Signaling Peptides and Proteins
- Xenopus
- Xenopus Proteins