A comparison of contractile properties in the preferred and nonpreferred leg in a mixed sample of dystrophic patients.

Abstract

No study of how muscle contractile function is related to limb preference in human muscular dystrophy is presently available. The purpose of this study was to determine if the ankle plantarflexor (PF) and dorsiflexor (DF) muscle groups of the preferred leg are more or less affected than the nonpreferred one in a mixed sample of myotonic and limb-girdle patients. Measurements of lower limb preference were made as well as of PF and DF evoked and voluntary contractile responses. Isometric contractile properties and peak values for torque production during maximum isometric twitch and voluntary contractions were measured. No significant difference was found in terms of contractile properties between the preferred and nonpreferred leg for both DF and PF muscle groups, except for the large PF twitch torque observed in the nonpreferred side (P less than 0.05). These results, however, reveal a clear tendency for both muscle groups on the preferred side to be weaker than those on the nonpreferred side. This last finding, in conjunction with the equally if not presumably stronger PF/DF muscles on the preferred leg of healthy adult subjects, would suggest that the equivalent bilateral muscle force observed in the present study may be interpreted as giving support to the hypothesis that overwork or overuse of dystrophic muscles may be harmful in weakening the musculature.