Expression and function of ETA and ETB receptors in SSc.
review · Level V
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- Record sourced from PubMed, PMID 18784135.
- Also identified by DOI 10.1093/rheumatology/ken274.
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Abstract
Endothelin (ET) receptors are widely expressed within the human body with one of their major functions being regulation of the vascular tone. Pulmonary arterial hypertension and other complications associated with SSc are related to the function and or dysregulation of these receptors. As ET receptors also play a crucial role in SSc, this review will discuss the expression and physiological functions of ET receptors in the human organism, their signalling pathways, the complications of diseases they are associated with and their importance as a therapeutic target in SSc.
Medical subject headings
- Receptor, Endothelin A
- Receptor, Endothelin B
- Scleroderma, Systemic
- Signal Transduction