Pro- and anti-fibrotic effects of TGF-beta in scleroderma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18784145.
- Also identified by DOI 10.1093/rheumatology/ken275 and PMC identifier 3292795.
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Abstract
The University of California at Davis 200 and 206 (UCD-200/206) lines of chickens have proven to be the animal model that best reflects the situation in human SSc. We have demonstrated a misbalance of pro-fibrotic (TGF-beta1) and anti-fibrotic (TGF-beta2 and -beta3) TGF-beta isoforms as a possible cause for fibrotic alterations in this model. This opens new avenues for diagnosis and therapy for this still intractable condition.
Medical subject headings
- Scleroderma, Systemic
- Skin
- Transforming Growth Factor beta