A mutation in hairless dogs implicates FOXI3 in ectodermal development.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18787161.
- Also identified by DOI 10.1126/science.1162525.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.
Medical subject headings
- Dog Diseases
- Dogs
- Ectoderm
- Ectodermal Dysplasia
- Forkhead Transcription Factors
- Frameshift Mutation