Uremic lung: new insights into a forgotten condition.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18794816.
- Also identified by DOI 10.1038/ki.2008.390.
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Abstract
The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water channels. AKI also affects the brain, heart, liver, bone marrow, and gastrointestinal tract. Klein et al. now demonstrate that interleukin-6 is a direct mediator of AKI-induced lung changes.
Medical subject headings
- Acute Kidney Injury
- Lung Diseases
- Uremia