Renin-angiotensin system blockade and diabetes: moving the adipose organ from the periphery to the center.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18794817.
- Also identified by DOI 10.1038/ki.2008.391.
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Abstract
Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.
Medical subject headings
- Diabetes Mellitus
- Renin-Angiotensin System