FunNet: an integrative tool for exploring transcriptional interactions.
basic_science · Level V
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- Record sourced from PubMed, PMID 18799481.
- Also identified by DOI 10.1093/bioinformatics/btn492.
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Abstract
We describe here an exploratory tool, called FunNet, which implements an original systems biology approach, aiming to improve the biological relevance of the modular interaction patterns identified in transcriptional co-expression networks. A suitable analytical model, involving two abstraction layers, has been devised to relate expression profiles to the knowledge on transcripts' biological roles, extracted from genomic databases, into a comprehensive exploratory framework. This approach has been implemented into a user-friendly web tool to promote its open use by the community. http://www.funnet.info
Medical subject headings
- Gene Regulatory Networks
- Software
- Transcription, Genetic