Encapsulation of semiconducting polymers in vault protein cages.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18803422.
- Also identified by DOI 10.1021/nl080537r and PMC identifier 3046045.
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Abstract
We demonstrate that a semiconducting polymer [poly(2-methoxy-5-propyloxy sulfonate phenylene vinylene), MPS-PPV] can be encapsulated inside recombinant, self-assembling protein nanocapsules called "vaults". Polymer incorporation into these nanosized protein cages, found naturally at approximately 10,000 copies per human cell, was confirmed by fluorescence spectroscopy and small-angle X-ray scattering. Although vault cellular functions and gating mechanisms remain unknown, their large internal volume and natural prevalence within the human body suggests they could be used as carriers for therapeutics and medical imaging reagents. This study provides the groundwork for the use of vaults in encapsulation and delivery applications.
Medical subject headings
- Nanocapsules
- Semiconductors