Reversible pH lability of cross-linked vault nanocapsules.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18803423.
- Also identified by DOI 10.1021/nl080536z and PMC identifier 3046048.
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Abstract
Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10,000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible cross-linking of recombinant vaults such that they may be closed and opened in a controllable manner.
Medical subject headings
- Nanocapsules
- Nanoparticles
- Nanotechnology