Strontium modified biocements with zero order release kinetics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18804862.
- Also identified by DOI 10.1016/j.biomaterials.2008.08.026.
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Abstract
Strontium-substituted beta-TCP with the general formula Ca((3-x))Sr(x)(PO(4))(2) (0<x<1) was synthesized by calcination of powder mixtures with the appropriate stoichiometry and reacted with acidic monocalcium phosphate monohydrate (MCPM) to form a cementitious matrix of secondary calcium phosphates. The use of Sr-substituted beta-TCP as a reactant not only induced strontium substitution in the setting products but surprisingly it also favoured the formation of monetite (CaHPO(4)) as setting product, whereas Sr-free cements set to brushite (CaHPO(4).2H(2)O). Release experiments under dynamic conditions for up to 15 days revealed the release of Sr(2+) ions at dose ranges of 12-30 ppm with zero order release kinetic. Cement cytocompatibility was investigated by culturing human osteoblast cell line hFOB1.19 on cement surfaces whereas Sr-containing cements were as good as Sr-free cements in providing a template for cell growth and function.
Medical subject headings
- Bone Cements
- Calcium Phosphates
- Strontium