Building consensus spectral libraries for peptide identification in proteomics.
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- Record sourced from PubMed, PMID 18806791.
- Also identified by DOI 10.1038/nmeth.1254 and PMC identifier 2637392.
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Abstract
Spectral searching has drawn increasing interest as an alternative to sequence-database searching in proteomics. We developed and validated an open-source software toolkit, SpectraST, to enable proteomics researchers to build spectral libraries and to integrate this promising approach in their data-analysis pipeline. It allows individual researchers to condense raw data into spectral libraries, summarizing information about observed proteomes into a concise and retrievable format for future data analyses.
Medical subject headings
- Peptide Library
- Proteomics