Epstein-Barr virus associated modulation of Wnt pathway is not dependent on latent membrane protein-1.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18806872.
- Also identified by DOI 10.1371/journal.pone.0003254 and PMC identifier 2532746.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Previous studies have indicated that Epstein-Barr virus (EBV) can modulate the Wnt pathway in virus-infected cells and this effect is mediated by EBV-encoded oncogene latent membrane protein 1 (LMP1). Here we have reassessed the role of LMP1 in regulating the expression of various mediators of the canonical Wnt cascade. Contradicting the previous finding, we found that the levels of E-cadherin, beta-catenin, Glycogen Synthase Kinase 3ss (GSK3beta), axin and alpha-catenin were not affected by the expression of LMP1 sequences from normal B cells or nasopharyngeal carcinoma. Moreover, we also show that LMP1 expression had no detectable effect on the E-cadherin and beta-catenin interaction and did not induce transcriptional activation of beta-catenin. Taken together these studies demonstrate that EBV-mediated activation of Wnt pathway is not dependent on the expression of LMP1.
Medical subject headings
- Gene Expression Regulation, Neoplastic
- Gene Expression Regulation, Viral
- Herpesvirus 4, Human
- Viral Matrix Proteins
- Wnt Proteins