Formation of artificial lipid bilayers using droplet dielectrophoresis.
basic_science · Level V
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- Record sourced from PubMed, PMID 18813381.
- Also identified by DOI 10.1039/b807374k.
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Abstract
We describe the formation of artificial bilayer lipid membranes (BLMs) by the controlled, electrical manipulation of aqueous droplets immersed in a lipid-alkane solution. Droplet movement was generated using dielectrophoresis on planar microelectrodes covered in a thin insulator. Droplets, surrounded by lipid monolayers, were brought into contact and spontaneously formed a BLM. The method produced BLMs suitable for single-channel recording of membrane protein activity and the technique can be extended to create programmable BLM arrays and networks.
Medical subject headings
- Electrophoresis
- Lipid Bilayers