Perforated membrane method for fabricating three-dimensional polydimethylsiloxane microfluidic devices.
basic_science · Level V
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- Record sourced from PubMed, PMID 18813392.
- Also identified by DOI 10.1039/b807751g.
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Abstract
A procedure is described for making layer-to-layer interconnections in polydimethylsiloxane (PDMS) microfluidic devices. Thin (approximately 50 microm) perforated PDMS membranes are bonded to thicker (0.1 cm or more) PDMS slabs by means of thermally cured PDMS prepolymer to form a three-dimensional (3D) channel structure, which may contain channel or valve arrays that can pass over and under one another. Devices containing as many as two slabs and three perforated membranes are demonstrated. We also present 3D PDMS microfluidic devices for display and for liquid dispensing.