MSX-3D: a tool to validate 3D protein models using mass spectrometry.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18826958.
- Also identified by DOI 10.1093/bioinformatics/btn510.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The technique of chemical cross-linking followed by mass spectrometry has proven to bring valuable information about the protein structure and interactions between proteic subunits. It is an effective and efficient way to experimentally investigate some aspects of a protein structure when NMR and X-ray crystallography data are lacking. We introduce MSX-3D, a tool specifically geared to validate protein models using mass spectrometry. In addition to classical peptides identifications, it allows an interactive 3D visualization of the distance constraints derived from a cross-linking experiment. Freely available at http://proteomics-pbil.ibcp.fr
Medical subject headings
- Mass Spectrometry
- Protein Conformation
- Software