Preservation of the kidney by carbon monoxide: a black swan phenomenon.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18827798.
- Also identified by DOI 10.1038/ki.2008.423 and PMC identifier 3075883.
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Abstract
Nakao and colleagues demonstrate that carbon monoxide added to organ preservation solution reduces donor-kidney injury that occurs after cold storage and transplantation and improves the survival of the recipient. These findings are important because they highlight the role of the cytochrome P450 system in the pathogenesis of donor-kidney injury and they suggest a strategy for preserving the donor kidney, namely, the addition of carbon monoxide to organ preservation solution.
Medical subject headings
- Carbon Monoxide
- Organ Preservation
- Organ Preservation Solutions