Animal models of sepsis and its complications.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18827799.
- Also identified by DOI 10.1038/ki.2008.442.
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Abstract
Most currently used animal sepsis models fail to adequately replicate the clinical problem and, therefore, have only limited utility for investigating pathophysiological mechanisms or testing the efficacy of new therapeutic agents. Recent experimental findings support this view and suggest that models of acute infection in mice with pre-existing renal dysfunction may be useful in the development pathway for new therapeutic agents for sepsis.
Medical subject headings
- Disease Models, Animal
- Kidney Diseases
- Sepsis