Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18829522.
- Also identified by DOI 10.1158/0008-5472.CAN-08-1132.
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Abstract
Pancreatic cancer--a tumor displaying a particularly abundant stromal reaction--is notorious for its poor prognosis. Recent studies, via newly developed orthotopic models, provide compelling evidence of an important role for pancreatic stellate cells (PSC) in pancreatic cancer progression. Characterization of the mechanisms mediating PSC-cancer interactions will lead to the development of much needed alternative therapeutic approaches to improve disease outcome.
Medical subject headings
- Pancreas
- Pancreatic Neoplasms
- Stromal Cells