Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients.
case_series · Level IV
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Abstract
Six drug-free obsessive-compulsive patients were given single photon emission computerized tomography scans before and during treatment with fluoxetine. The treatment significantly reduced the patients' "hyperfrontality," as determined by the ratio between medial-frontal and whole cerebral cortex blood flow, and significantly lowered ratings of obsessive-compulsive and anxiety symptoms.
Medical subject headings
- Cerebrovascular Circulation
- Fluoxetine
- Frontal Lobe
- Obsessive-Compulsive Disorder