Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 18831695.
- Also identified by DOI 10.1086/592304 and PMC identifier 3672984.
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Abstract
This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T-->C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P = .008) and 5.13 (P = .02). Prospective studies determining potential clinical usefulness are now warranted.
Medical subject headings
- HIV Protease Inhibitors
- Oligopeptides
- Polymorphism, Single Nucleotide
- Pyridines
- Receptors, Steroid