Drug toxicity, HIV progression, or comorbidity of aging: does tipranavir use increase the risk of intracranial hemorrhage?

Justice, Amy C; Zingmond, David S; Gordon, Kirsha S; Fultz, Shawn L; Goulet, Joseph L; King, Joseph T; Bravata, Dawn M; Valdez, Hernan et al. · Clin Infect Dis · 2008

retrospective_cohort · Level III

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Abstract

The US Food and Drug Administration has issued a warning that tipranavir may be associated with increased risk of intracranial hemorrhage. We studied 2 large cohorts to estimate the background rate of intracranial hemorrhage and compared it with rates reported among persons who had been exposed to tipranavir.

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