High-speed, miniaturized fluorescence microscopy in freely moving mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18836457.
- Also identified by DOI 10.1038/nmeth.1256 and PMC identifier 2828344.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A central goal in biomedicine is to explain organismic behavior in terms of causal cellular processes. However, concurrent observation of mammalian behavior and underlying cellular dynamics has been a longstanding challenge. We describe a miniaturized (1.1 g mass) epifluorescence microscope for cellular-level brain imaging in freely moving mice, and its application to imaging microcirculation and neuronal Ca(2+) dynamics.
Medical subject headings
- Microscopy, Fluorescence
- Miniaturization
- Movement