Therapeutic use of infliximab in tuberculosis to control severe paradoxical reaction of the brain and lymph nodes.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 18840076.
- Also identified by DOI 10.1086/592695.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Paradoxical reactions are immune-mediated exacerbations of disease triggered by tuberculosis treatment. Paradoxical reactions involving the central nervous system may be life threatening. Infliximab (tumor necrosis factor antibody) profoundly inhibits cellular immune responses to Mycobacterium tuberculosis. We describe a case in which infliximab was used to control steroid-resistant tuberculosis paradoxical reaction involving the central nervous system.
Medical subject headings
- Anti-Inflammatory Agents
- Antibodies, Monoclonal
- Brain
- Immunologic Factors
- Lymph Nodes
- Tuberculosis