Autophagy: a sweet process in diabetes.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18840355.
- Also identified by DOI 10.1016/j.cmet.2008.09.001.
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Abstract
Autophagy is inhibited by the insulin-amino acid-mTOR signaling pathway. Two papers in this issue of Cell Metabolism (Ebato et al., 2008; Jung et al., 2008) provide evidence that basal autophagy is necessary to maintain the architecture and function of pancreatic beta cells and that its induction in diabetic mice protects beta cells against damage by oxidative stress.
Medical subject headings
- Autophagy
- Diabetes Mellitus