Welcoming Foxa2 in the bile acid entourage.
Level V
Where this comes from
- Record sourced from PubMed, PMID 18840356.
- Also identified by DOI 10.1016/j.cmet.2008.09.009.
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Abstract
Homeostatic regulation of bile acid metabolism and biliary lipid secretion is critical to prevent enterohepatic diseases. Kaestner and coworkers (Bochkis et al., 2008) show that loss of forkhead box transcription factor Foxa2 in the liver leads to hepatic injury due to downregulation in the expression levels of bile acid transporters and detoxification enzymes.
Medical subject headings
- Bile Acids and Salts
- Hepatocyte Nuclear Factor 3-beta