Efficacy of fixed minidose warfarin prophylaxis in total hip replacement.
rct · Level II
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- Record sourced from PubMed, PMID 1884058.
- Also identified by PMC identifier 1670497.
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Abstract
To determine whether a small fixed perioperative dose of warfarin would prevent deep vein thrombosis after total hip replacement. Prospective, randomised, double blind placebo controlled trial. Winford Orthopaedic Hospital, Bristol. 148 patients having primary total hip replacement. Warfarin 1 mg given daily for one week before and three weeks after surgery. Deep vein thrombosis diagnosed by the iodine-125 labelled fibrinogen uptake method. Deep vein thrombosis occurred in 25 (34%) of the patients given warfarin and 19 (26%) of the controls (difference 8%; 95% confidence interval -6.8% to 22.8%). Fixed minidose warfarin does not prevent deep vein thrombosis after total hip replacement.
Medical subject headings
- Hip Prosthesis
- Postoperative Complications
- Thrombosis
- Warfarin