Liver transplantation after paracetamol overdose.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 1884059.
- Also identified by PMC identifier 1670505.
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Abstract
To evaluate the role of liver transplantation after paracetamol overdose. Prospective study of consecutive candidates for transplantation and performance of transplantation over 18 months. Liver unit, King's College Hospital, London. Fulfilment of indicators of poor prognosis, selection for transplantation, transplantation, survival. 30 of 37 patients considered to have a reasonable prognosis with intensive medical care survived. Of 14 of 29 patients considered to have a very poor prognosis and registered for urgent liver transplantation, six received liver transplants, four of whom survived, while seven died and one survived without a transplant. Three of 15 patients with poor prognostic indicators but not selected for transplantation survived. Liver transplantation will have a definite but limited role in the management of fulminant hepatic failure induced by paracetamol.
Medical subject headings
- Acetaminophen
- Chemical and Drug Induced Liver Injury
- Liver Transplantation