DNA repair by the MRN complex: break it to make it.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18854148.
- Also identified by DOI 10.1016/j.cell.2008.09.027.
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Abstract
Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of the nuclease activity of Mre11 for mammalian genome maintenance and present a molecular view of its active site.
Medical subject headings
- DNA Breaks, Double-Stranded
- DNA Repair
- DNA Repair Enzymes