Spectraplakins: the cytoskeleton's Swiss army knife.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18854149.
- Also identified by DOI 10.1016/j.cell.2008.09.023.
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Abstract
Spectraplakins are multifunctional proteins that interact with all three types of cytoskeletal filaments. In this issue, Wu et al. (2008) demonstrate a new actin-dependent ATPase activity for the spectraplakin ACF7 that allows it to guide microtubule ends along actin stress fibers to focal adhesions, promoting disassembly of adhesion contacts and hence cell movement.
Medical subject headings
- Cytoskeleton
- Microfilament Proteins