Stressing the brain, fattening the body.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18854151.
- Also identified by DOI 10.1016/j.cell.2008.09.030.
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Abstract
Obesity is characterized by chronic activation of inflammatory pathways in peripheral tissues. In this issue, Zhang et al. (2008) demonstrate that inflammation also occurs in the central nervous system where it disrupts activity of the hypothalamus leading to resistance to leptin that is mediated by activation of IKK and the endoplasmic reticulum stress response.
Medical subject headings
- Hypothalamus
- Obesity
- Overnutrition